Abstract: Based on remote sensing images, digital elevation model (DEM) and other information of the Guanzhong region, in this paper the spatiotemporal change of NDVI at different scales (such as the grid units, terrain units, slope units and administrative units) in the Guanzhong region during the period from 1986 to 2007 was analyzed using the theory of geographic information images and RS and GIS means. The results show that the NDVI in the Guanzhong region was increased by 20.91% during the period of 1986-2007, and its increase rate was about 2.31 times of that during the period of 1986-2000. The NDVI in all the geomorphologic units was increased in an order of loess tableland > loess ridge > mountain > plain > loess plateau. The NDVI in all the slope zones was also increased, and its increase rate was increased with the increase of slope. The increase rate of NDVI in all the prefectures and cities was in an order of Weinan City > Tongchuan City > Baoji City > Xi’an City > Xianyang City. The spatiotemporal change of NDVI in the Guanzhong region was caused by land use/cover change, and the improvement of vegetation coverage in the study area was brought about by implementing the project of returning land for farming to forest and grassplot.