Abstract: Based on the SPOT VGTNDVI data during the period from 1998 to 2011, in this paper the spatial and temporal variation of vegetation coverage in the Hedong region of Gansu Province was systematically studied using the NDVI average method, retrieval of vegetation coverage and linear regression trend analysis. The results show that the NDVI in the north of the Hedong region was lower than that in the south. Temporally, NDVI in the study area in recent 14 years was holistically in an increase trend with an increase rate of 0.028·(10a-1). In which it was decreased in the first 4 years (from 0.392 in 1998 to 0.314 in 2001); in the later 10 years, it was increased in a fluctuation way (from 0.330 in 2002 to 0.378 in 2011). Temporally, NDVI in recent 14 years was in an increase trend in the northerncentral mountainous region in south Gansu Province, southern parts of the central Gansu Plateau, but it was in a certain decrease in the southeast of the east Gansu Plateau and the grasslands in south Gansu Province.