Abstract: Typical Metazoa mitochondrion genome contains 37 genes: 2 for rRNA, 13 for protein coding genes and 22 for tRNA. Rearrangement of mitochondrial gene orders constitutes an ideal model for studying phylogenetic investigation. In this paper, we downloaded 2 511 Mmetazoa mitochondrion genomes from NCBI database, and selected their gene orders with perl scripts. The rearrangement of gene orders was summarized from five aspects, including the gene reverse, gene reversions, gene lost and duplicate, share clusters and transitions. The progresses of Metazoa mitochondrial gene order rearrangement in recent years were also reviewed. Many classical rearrangement patterns were proved in gene order comparisons among different species categories, and the relationships between phylogeny and mitochondrial gene order rearrangement were revealed.