Abstract: Apocynum and lithium have similar efficacies for human body, and a certain amount of lithium concentrates in Apocynum .The lithium content of Apocynum affects its efficacies. In this paper, [WTBX]Apocynum hedersonii[WTBZ] and [WTBX]A. [WTBX]lancifolium[WTBZ] were chosen as the experimental materials for the pot experiments, the effects of different lithium concentrations on the seedling growth and lithium accumulation of [WTBX]Apocynum[WTBZ] were analyzed. Additionally, the maximum lithium accumulations of two [WTBX]Apocynum[WTBZ] species were also discussed. The results showed that lithium was not the necessary element for the growth of [WTBX]Apocynum[WTBZ], the main reason was that high lithium concentration had a restraining influence, which was increasingly apparent with the increase of lithium concentration. The lithium content of leaf was higher than that of root and stem, the leaf of [WTBX]A. lancifolium [WTBZ]had stronger lithiumresistance than that of [WTBX]A. hedersonii.[WTBZ] In different treatments, the lithium accumulation of leaf reached the maximum in the treatment with the lithium concentration of 100 mg•kg-1, but its increment was limited. The lithium accumulation of leaf in the treatment of 25 mg•kg-1 was lower than that in the treatment of 100 mg•kg-1, but the former was still higher than that the controlled group and had smaller restrictions. Therefore, it is suitable for planting [WTBX]Apocynum[WTBZ] that the lithium concentration should be lower than 25 mg•kg-1 based on the effects of different lithium concentrations on the production of [WTBX]Apocynum[WTBZ] and its medicinal effects.